Abstract: As humanity looks toward the stars, the prospect of colonizing other planets, particularly Mars, becomes increasingly feasible. However, the enormous challenges posed by space travel, environmental hostility, and human biological limitations have sparked new avenues of exploration. One such avenue involves the use of advanced artificial intelligence (AI) and robotics to prepare extraterrestrial environments and potentially resynthesize human life itself. This paper explores how AI could lead the charge in space colonization by autonomously constructing habitats, terraforming hostile planets, and ultimately recreating human life through synthetic biology and cloning. By considering AI as not only a tool but a caretaker and creator of future civilizations, we open a discussion on the ethical, philosophical, and technological implications of this groundbreaking approach. The role of AI in resynthesizing human biology, preserving culture, and shaping human evolution across the cosmos invites us to rethink our identity, our legacy, and our future as a multi-planetary species.